Gene scissors: CRISPR's influence in dentistry - Click here

CRISPR-Cas technology, often referred to as gene scissors, is transforming dentistry by enabling precise gene editing at the molecular level. In dental research and clinical applications, CRISPR shows promise in regenerative dentistry, oral cancer therapy, and management of genetic dental disorders.

CRISPR has been explored for stimulating dentin–pulp regeneration, modifying stem cells for periodontal tissue engineering, and targeting oncogenes involved in oral squamous cell carcinoma. It also offers potential in correcting mutations responsible for conditions such as amelogenesis imperfecta and dentinogenesis imperfecta.

Although still largely experimental, CRISPR technology represents a significant advancement toward personalized and minimally invasive dental therapies, with ongoing research focused on safety, ethical considerations, and clinical translation.