Nuclear Aberrations in Gingival Epithelium of Chronic Periodontitis Patients - Click here

Nuclear aberrations in the gingival epithelium are important cytological indicators of chronic inflammation and genotoxic stress in chronic periodontitis. Persistent periodontal inflammation leads to increased cellular turnover and DNA damage, resulting in observable nuclear changes.

Common nuclear aberrations include micronuclei formation, binucleation, karyorrhexis, karyolysis, and pyknosis. These alterations reflect chromosomal instability, apoptosis, and oxidative stress caused by inflammatory mediators and bacterial toxins present in periodontal disease.

Assessment of nuclear aberrations using exfoliative cytology serves as a noninvasive tool to evaluate epithelial damage, disease severity, and potential malignant transformation risk in chronic periodontitis patients.